2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2419):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-152648
    N6-Ethyl-2’-O-methyladenosine
    N6-Ethyl-2’-O-methyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N6-Ethyl-2’-O-methyladenosine
  • HY-152406
    3’-Beta-C-Methyl-5-methylcytidine
    3’-Beta-C-Methyl-5-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    3’-Beta-C-Methyl-5-methylcytidine
  • HY-154052
    5′-Amino-2′,5′-dideoxyuridine
    5′-Amino-2′,5′-dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5′-Amino-2′,5′-dideoxyuridine
  • HY-154643
    9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-9H-purin-2-amine
    9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-9H-purin-2-amine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-9H-purin-2-amine
  • HY-154002
    4-Amino-5-cyano-1-(2-deoxy-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
    4-Amino-5-cyano-1-(2-deoxy-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects.
    4-Amino-5-cyano-1-(2-deoxy-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
  • HY-145973
    3'OMe-m7GpppAmpG
    3’OMe-m7GpppAmpG (m7(3'OMeG)(5')ppp(5')(2'OMeA)pG) is a trinucleotide Cap1 analog with the structure m7 (3'OMeG)(5') ppp (5')(2'OMeA) pG, and also functions as a cis-acting ligase ribozyme inhibitor. 3’OMe-m7GpppAmpG effectively reduces free 5'-triphosphate groups on RNA transcripts, thereby enabling efficient co-transcriptional capping of in vitro transcribed mRNA. 3’OMe-m7GpppAmpG is not only widely used in the preparation of modified mRNA including trivalent influenza vaccine candidates, but also applicable to studies related to SARS-CoV-2 infection and other relevant research.
    3'OMe-m7GpppAmpG
  • HY-W559353
    1-(3-Beta-amino-2,3-dideoxy-beta-d-threopenta-furanosyl)thymine
    1-(3-Beta-amino-2,3-dideoxy-beta-d-threopenta-furanosyl)thymine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1-(3-Beta-amino-2,3-dideoxy-beta-d-threopenta-furanosyl)thymine
  • HY-152500
    4-Deoxy-3’-β-C-methyluridine
    4-Deoxy-3’-β-C-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    4-Deoxy-3’-β-C-methyluridine
  • HY-152395
    N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine
    N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine
  • HY-152444
    5-Hydroxymethyl-2’-O-(2-methoxyethyl)uridine
    5-Hydroxymethyl-2’-O-(2-methoxyethyl)uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Hydroxymethyl-2’-O-(2-methoxyethyl)uridine
  • HY-W558459
    3’-O-t-Butyldimethylsilyladenosine
    3’-O-t-Butyldimethylsilyladenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    3’-O-t-Butyldimethylsilyladenosine
  • HY-154522
    2-(2,4-Dichlorobenzyl)thioadenosine
    2-(2,4-Dichlorobenzyl)thioadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2-(2,4-Dichlorobenzyl)thioadenosine
  • HY-152519
    5-(Aminomethyl)-2-thiouridine
    5-(Aminomethyl)-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-(Aminomethyl)-2-thiouridine
  • HY-154531
    2′,3′-Dideoxy-3′-fluoro-5-methylcytidine
    2′,3′-Dideoxy-3′-fluoro-5-methylcytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2′,3′-Dideoxy-3′-fluoro-5-methylcytidine
  • HY-152663
    6-Mthoxy-9-beta-D-(2-C-ethynyl-ribofuranosyl) purine
    6-Mthoxy-9-beta-D-(2-C-ethynyl-ribofuranosyl) purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 6-Mthoxy-9-beta-D-(2-C-ethynyl-ribofuranosyl) purine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    6-Mthoxy-9-beta-D-(2-C-ethynyl-ribofuranosyl) purine
  • HY-154541
    N2,N2-Dimethylamino-6-deamino adenosine
    N2,N2-Dimethylamino-6-deamino adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N2,N2-Dimethylamino-6-deamino adenosine
  • HY-154517
    N3-Cyanoethyl-5’-O-(4,4’-dimethoxytrityl)-2’-O-methyluridine
    N3-Cyanoethyl-5’-O-(4,4’-dimethoxytrityl)-2’-O-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    N3-Cyanoethyl-5’-O-(4,4’-dimethoxytrityl)-2’-O-methyluridine
  • HY-180744
    Aminoacetaldehyde
    Aminoacetaldehyde is a nucleoside metabolite.
    Aminoacetaldehyde
  • HY-49200
    DMT-2'-F-dC(Bz)-CE-Phosphoramidite
    DMT-2'-F-dC(Bz)-CE-Phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    DMT-2'-F-dC(Bz)-CE-Phosphoramidite
  • HY-154581
    5-(Furan-2-yl)-2’-O-methyl-5’-O-DMTr-cytidine
    5-(Furan-2-yl)-2’-O-methyl-5’-O-DMTr-cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-(Furan-2-yl)-2’-O-methyl-5’-O-DMTr-cytidine